[MCOH-EH] - diphtheria toxin work and vaccinations

[Swift, Melanie]

YES. Michelle I'd be glad to discuss offline. We have people working with high dose concentrated toxin, which has enough toxin for 70 lethal human doses in 0.1ml. I've spent some quality time researching this and speaking to experts at, CDC, NIH and the FDA.
Our high dose handlers get baseline and annual titers - this is a send-out lab and protection for normal bacteria exposure is not adequate level for exposure to preformed toxin. We boost based on titer.
Low dose handlers just need booster q 10y.
Would be happy to share what we've learned.
Sent from my iPhone

On Aug 3, 2015, at 1:32 PM, Gochnour, Michelle K. <michelle.gochnour at seattlechildrens.org<mailto:michelle.gochnour at seattlechildrens.org>> wrote:

If you have workers using diphtheria toxin, how frequently do you provide vaccination booster?  Do you titer as well to ensure levels of antibody (IgG)?  I have a researcher suggesting he should have more frequent boosters than 10 years (as needed for tetanus).  Thoughts?

Michelle
Michelle Kom Gochnour, MN, RN, COHN-S
Senior Occupational Health Consultant | Occupational Health Services
Seattle Children's Hospital

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michelle.gochnour at seattlechildrens.org<mailto:michelle.gochnour at seattlechildrens.org>

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