[MCOH-EH] Can Heplisav-B be used for booster dose?

Tim Crump crumpt at ohsu.edu
Tue Aug 20 12:07:34 PDT 2019

We are transitioning over to mostly Heplisav-B for our Hep B vaccinations.  Does anyone have thoughts whether Heplisav-B can be used for a booster dose?  (For example, if a worker had a full documented Hep B series in 2001, but never got a titer till now and it is negative, can we use one Heplisav-B for booster dose, and if the worker has a positive titer after, call them long-term immune?)

*         Our drug rep says no, that Heplisav is always given as a series of 2 and never as a single dose.

*         To my mind though, anyone with a full Hep B series and a subsequent positive titer has long term immunity, and it shouldn't matter which vaccine boosts to demonstrate this.

What do others think?  The advantage of boosting w/ Heplisav-B would be that if the titer is negative, it would take a lot less time to complete the second series.  Best, Tim

Tim Crump, MSN, FNP
Tim Crump, MSN, FNP
Family Nurse Practitioner
Multnomah Pavilion 1 SE, Suite 1110
Occupational Health
Healthcare Human Resources

Oregon Health & Science University
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Mail code: UHN 89
Portland, OR 97239-3098
Department Phone: 503-494-5271
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Email: crumpt at ohsu.edu<mailto:crumpt at ohsu.edu>

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