[MCOH-EH] Can Heplisav-B be used for booster dose?

Higazi, Patricia Patricia.Higazi at chkd.org
Wed Aug 21 06:52:32 PDT 2019

We have been using Heplisav for titer negative employees since October last year - so far 98.2 % positive titers post booster (58 ee)

Patricia Higazi  MSN RN COHN
Occupational Health Director
Children's Hospital of The King's Daughters
Norfolk, Virginia 23507
Tel: 757 668 7852
Fax: 757 668 8775

From: MCOH-EH [mailto:mcoh-eh-bounces at mylist.net] On Behalf Of Kim.Norton2 at hcahealthcare.com
Sent: Wednesday, August 21, 2019 8:37 AM
To: mcoh-eh at mylist.net
Subject: Re: [MCOH-EH] Can Heplisav-B be used for booster dose?
Importance: High


Hi Tim,
Per the MMWR / January 12, 2018 / Vol. 67 / No. 1 US Department of Health and Human Services/Centers for Disease Control and Prevention.

"Response to Revaccination"
A challenge dose of HepB vaccine may be used to determine the presence of vaccine-induced immunologic memory through generation of an anamnestic response. The term "booster dose" has been used to refer to a dose of HepB vaccine administered after a primary vaccination series to provide" (page 12, bottom right).

We utilize this method and have found that the majority will convert to immunity status.
However, we use the Engerix Hep B (01 ml). After booster vaccination, we schedule a Titer retest 6 - 8 weeks later

Thank you,
Kim A. Norton, B.S.N., R.N., O.H.N.
Occupational Health Services & Injury Coordinator
It is better to prevent disease rather than to try to find a cure for diseases after they occur.
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Kim.Norton2 at hcahealthcare.com<mailto:Kim.Norton2 at hcahealthcare.com>
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Central Florida Regional Hospital
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From: MCOH-EH <mcoh-eh-bounces at mylist.net> On Behalf Of Tim Crump
Sent: Tuesday, August 20, 2019 3:08 PM
To: MCOH-EH <mcoh-eh at mylist.net>
Subject: {EXTERNAL} [MCOH-EH] Can Heplisav-B be used for booster dose?

We are transitioning over to mostly Heplisav-B for our Hep B vaccinations.  Does anyone have thoughts whether Heplisav-B can be used for a booster dose?  (For example, if a worker had a full documented Hep B series in 2001, but never got a titer till now and it is negative, can we use one Heplisav-B for booster dose, and if the worker has a positive titer after, call them long-term immune?)

*         Our drug rep says no, that Heplisav is always given as a series of 2 and never as a single dose.

*         To my mind though, anyone with a full Hep B series and a subsequent positive titer has long term immunity, and it shouldn't matter which vaccine boosts to demonstrate this.

What do others think?  The advantage of boosting w/ Heplisav-B would be that if the titer is negative, it would take a lot less time to complete the second series.  Best, Tim

Tim Crump, MSN, FNP
Tim Crump, MSN, FNP
Family Nurse Practitioner
Multnomah Pavilion 1 SE, Suite 1110
Occupational Health
Healthcare Human Resources

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