[MCOH-EH] [EXTERNAL] Narcan availability in research labs

[hudson.warner at gmail.com]

Make sure you know the opioids and are fully prepared.  We had some vet researchers who wanted to dart very large animals with carfentanil which is 100x more potent than fentanyl; protocol complicated as is availability; some institutions require on hand anesthesiology when darting in the event of a human exposure as many many doses of Narcan required.  In the end at UCLA the research using carfentanil was scrapped.  Warner

 

From: MCOH-EH <mcoh-eh-bounces at mylist.net> On Behalf Of Swift, Melanie D., M.D., M.P.H. via MCOH-EH
Sent: Wednesday, November 2, 2022 2:56 PM
To: MCOH-EH <mcoh-eh at mylist.net>
Cc: Swift, Melanie D., M.D., M.P.H. <Swift.Melanie at mayo.edu>
Subject: Re: [MCOH-EH] [EXTERNAL] Narcan availability in research labs

 

Hi Shuchi,

We don’t have any researchers working with opioids in a way that would make an accidental laboratory exposure clinically significant. (Ingestion would be a problem, but then ingestion of most things they are researching with would be a problem!) Most laboratory accidents involve contact with intact skin (small amounts, easily flushed), needlesticks which would be a miniscule dose, or respiratory exposure which shouldn’t be a concern working with opioids. At least we haven’t had a protocol that involved an ultrapotent experimental opioid that would pose that concern. 

 

Melanie

 

Melanie Swift, MD, MPH

(she/her)
Vice Chair, Division of Public Health, Infectious Diseases and Occupational Medicine

Medical Director, Mayo Clinic Physician Health Center <https://www.mayoclinic.org/departments-centers/preventive-occupational-aerospace-medicine/physician-health-center/referrals> 

Associate Medical Director, Occupational Health Service

_______________________________
Mayo Clinic
200 First Street SW
Rochester, MN 55905

 

From: MCOH-EH <mcoh-eh-bounces+swift.melanie=mayo.edu at mylist.net <mailto:mcoh-eh-bounces+swift.melanie=mayo.edu at mylist.net> > On Behalf Of Shuchi Agarwal
Sent: Tuesday, November 1, 2022 12:07 PM
To: mcoh-eh at mylist.net <mailto:mcoh-eh at mylist.net> 
Subject: [EXTERNAL] [MCOH-EH] Narcan availability in research labs

 

Hello everyone,

 

I am wondering if any of your institutions have a procedure for research labs that work with opioids to have narcan available in the case of an accidental exposure?

 

If so, would you be willing to connect to discuss further?

 

Thanks in advance. 

 

Warm regards,

Shuchi 

 

Shuchi Agarwal MD MPH

Assistant Attending Employee Health 

Memorial Sloan Kettering Cancer Center

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